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Weakness in your mother's leg muscles could be a result of problems other than her temporal arteritis or the prednisone treatment she is receiving. What does her managing physician say? Has she brought this symptom to the attention of her doctor? She should. The causes and development of this disorder are not fully understood, and treatment options seem to be rather limited. However, Azathioprine, methotrexate, and dapsone have been used in patients with unacceptable corticosteroid side effects, although evidence of efficacy is sparse.